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Watch real women with early breast cancer with a high risk of coming back share their journeys with KISQALI
More women with HR+, HER2- stage 2 and 3 early breast cancer are taking KISQALI with an aromatase inhibitor. Hear their stories.
Watch how Lindsey manages her family, career, and treatment.
LINDSEY:
I'm Lindsey.
I am a mom to two awesome kids, Charlotte and Jackson.
And wife to my husband, Fred.
I work in law enforcement as a first responder, and I'm a K-9 handler.
Life at home for us, it's a beautiful chaos.
It is never an empty second of the day.
Between sports, playing outside, running around the house, fishing, camping, stories together, snacks, gotta have snacks all the time.
You never know when there's going to be a meltdown.
"Stop." "What?" "Stop.”
Likewise, I never know when the phone will ring at 3 A.M., and somebody needs a dog.
“Here.”
Maggie is my partner.
“Up, up, up, up.”
What we do is we sweep everything from sports stadiums to political events.
“Yes.”
Everyone loves the dog.
Seeing smiles and being able to bridge that relationship between law enforcement and the community; that is what Maggie does, I just, you know, I just carry the leash.
Balancing being on duty and being a mom, it's definitely tricky.
You have to just be a step ahead.
The moment I felt a lump, my doctors followed through with all the diagnostic testing, and I was diagnosed with HR-positive, HER2-negative early-stage breast cancer with a high risk of coming back.
I was in a moment of complete shock.
I didn't even go home and tell my husband what was going on.
I just sat in the parking lot and ran through every thing; it was like a tornado of emotion.
Not being there at birthday parties, weddings, graduations, my kids forgetting me.
It was very overwhelming.
Once I overcame speaking it into words and actually making it real, I just became fully immersed.
I wanted to know, I wanted to be ahead of things, I wanted to have a game plan.
It was eight weeks of chemo, followed by double mastectomy, hormone replacement therapy, and a total hysterectomy.
Somewhere in the middle of it all, my doctor brought up KISQALI.
I went to the website, reviewed it, researched it, and I was like, “I’m in, where do I sign?”
I wanted to have something that was going to help reduce the risk of breast cancer coming back.
My outlook on life has changed tremendously after breast cancer.
I live in all of the small details, I appreciate the small details.
My kids laugh, I appreciate my kids laugh.
I'm just so grateful to be here.
There is joy going through this fight, through this struggle.
When you're pushed in the corner and you have nowhere to go but forward, you go forward.
Looking back, it's like, man, I did not think I had that in me, you know?
And I now know I do.
I'm Lindsey, and I never walk away from a challenge.
Because you might not ever see breast cancer coming.
But some of us, we’re always on duty.
VOICEOVER:
What is KISQALI?
KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:
- in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
- that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
- an aromatase inhibitor as the first endocrine-based therapy; or
- fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy
It is not known if KISQALI is safe and effective in children.
IMPORTANT SAFETY INFORMATION
KISQALI may cause serious side effects, including:
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:
- trouble breathing or shortness of breath
- cough with or without mucus
- chest pain
Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.
- Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
- Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:
- yellowing of your skin or the whites of your eyes (jaundice)
- dark or brown (tea-colored) urine
- feeling very tired
- loss of appetite
- pain on the upper right side of your stomach area (abdomen)
- bleeding or bruising more easily than normal
Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.
What should I tell my health care provider before taking KISQALI?
Before you take KISQALI, tell your health care provider if you:
- have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
- have ever had a heart attack
- have a slow heartbeat (bradycardia)
- have high blood pressure that is not controlled
- have decreased thyroid gland function (hypothyroidism)
- have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
- have fever, chills, or any other signs or symptoms of infection
- have liver problems
- have kidney problems
- are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
- If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
- Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
- Talk to your health care provider about birth control methods that may be right for you during this time
- If you become pregnant or think you are pregnant, tell your health care provider right away
- are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.
What should I avoid while taking KISQALI?
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.
The most common side effects of KISQALI in people with early breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- increased kidney function test
- decreased platelet counts
- nausea
- headache
- tiredness
The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- nausea
- increased kidney function test
- tiredness
- decreased platelet counts
- diarrhea
- vomiting
- headache
- constipation
- hair loss
- cough
- rash
- back pain
- low blood sugar level
KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information at KISQALI.com.
“When there’s nowhere to go but forward, you go forward.” – LINDSEY
As a mother, dog handler, and first responder, Lindsey leads a busy life. One minute, she’s teaching her kids to read. The next, she’s protecting her community. So when she learned that her HR+, HER2- early breast cancer could return, she jumped into action and spoke with her doctor about KISQALI with an aromatase inhibitor.
Meet Laurie, a researcher and sci-fi enthusiast.
LAURIE:
I'm Laurie.
And I'm so much more than my breast cancer.
I'm a total sci-fi nerd.
When I'm not nerding out for fun at cosplay conventions, I'm a prospect researcher in Cambridge.
I just love everything about exploring and enjoying the wonders that are out there waiting for us.
A few years ago, my life took an unexpected plot twist.
I'd always been told to do self-exams.
That was that sudden moment of a very hard lump like I had never, ever felt before, and I need to call my doctor in the morning.
Biopsy confirmed it was invasive ductal carcinoma… early-stage breast cancer.
I had a lumpectomy, which revealed some of my lymph nodes were affected.
It's scary to not know.
My treatment started right away.
Chemo then rounds of radiation, all while parenting and working.
I felt lost. Helpless. Terrified.
Besides the fact that I process things through writing... maybe I can help other people understand what I'm going through.
But then maybe someday down the line, it might be one of them, and they'll, they'll know what to expect because I wrote about it.
I was never truly alone.
My husband was always by my side.
It's just so important to have those moments with the people you love.
We even had a head shaving party, because if you're going to lose your hair, make it an event, right?
My son even buzzed some off.
Other friends knitted me beautiful hats.
Loved ones rallied and my world expanded.
I felt so grateful to have these great friends.
After initial treatment, the results of my scans showed things were headed in the right direction.
But when I saw the numbers for the risk of cancer coming back, I thought that's way too high.
That's when I learned about KISQALI.
I was excited to find something that could possibly reduce the risk of recurrence.
Taking KISQALI with an aromatase inhibitor felt like adding another layer to help protect myself.
The science made sense to me, and I liked knowing that there was a proactive way that I could help protect my tomorrow.
Now I'm cherishing family dinners more, and movie nights more… along with all of those nerdy things I love.
I'm especially excited about my annual camping trip, where we make ice cream with liquid nitrogen.
I've always been inspired by stories of discovery and hope, and I hope my story can inspire others.
I'm Laurie, and I'm doing more today to help protect my tomorrow.
Because I'm more than just breast cancer.
VOICEOVER:
What is KISQALI?
KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:
- in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
- that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
- an aromatase inhibitor as the first endocrine-based therapy; or
- fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy
It is not known if KISQALI is safe and effective in children.
IMPORTANT SAFETY INFORMATION
KISQALI may cause serious side effects, including:
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:
- trouble breathing or shortness of breath
- cough with or without mucus
- chest pain
Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.
- Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
- Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:
- yellowing of your skin or the whites of your eyes (jaundice)
- dark or brown (tea-colored) urine
- feeling very tired
- loss of appetite
- pain on the upper right side of your stomach area (abdomen)
- bleeding or bruising more easily than normal
Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.
What should I tell my health care provider before taking KISQALI?
Before you take KISQALI, tell your health care provider if you:
- have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
- have ever had a heart attack
- have a slow heartbeat (bradycardia)
- have high blood pressure that is not controlled
- have decreased thyroid gland function (hypothyroidism)
- have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
- have fever, chills, or any other signs or symptoms of infection
- have liver problems
- have kidney problems
- are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
- If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
- Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
- Talk to your health care provider about birth control methods that may be right for you during this time
- If you become pregnant or think you are pregnant, tell your health care provider right away
- are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.
What should I avoid while taking KISQALI?
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.
The most common side effects of KISQALI in people with early breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- increased kidney function test
- decreased platelet counts
- nausea
- headache
- tiredness
The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- nausea
- increased kidney function test
- tiredness
- decreased platelet counts
- diarrhea
- vomiting
- headache
- constipation
- hair loss
- cough
- rash
- back pain
- low blood sugar level
KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information at KISQALI.com.
“The science made sense to me.” – LAURIE
When Laurie isn't doing research for a university, she's cosplaying sci-fi characters and reading about galaxies far away. But when she found out about the risk of her breast cancer coming back, she thought about her own potential risk—and chose KISQALI with an aromatase inhibitor.
See how Mona took the wheel after initial treatment.
MONA:
“Hello. Welcome aboard. Hello.”
I'm Mona, a born and raised New Yorker.
“Hello.”
Growing up, I loved driving.
And for me, to drive a bus...
“Next stop is our lovely 125th.”
I get to take people to where they need to go.
I'm making a difference to a lot of people each and every day.
I wouldn't change it for the world.
“Okay, what's this answer?”
MONA’S GRANDSON:
That's negative seven.
MONA:
“I’m gonna see the next page.”
My grandchildren are my heart.
They are my everything.
I get to be like a mommy all over again.
Sean is very smart.
He knows everything about the New York City transit system.
Aliyah, she's shy.
She reminds me a lot of me when I was little… but you overcome it.
I would love to see people that I grew up with so they could see me today.
Me going to work and being busy, I've always been like that.
That's just who I am.
But then, illness came for me.
I went in for a regular checkup, had the mammogram done, and that's when I got the diagnosis.
Stage two breast cancer.
I just broke down.
I didn't have any health issues.
No one in my family has a history so it’s just like, why me? Why me?
I just didn't understand it.
In life, we all go through tests.
This is just another test, and I'm just going to deal with this.
I kept my head down and moved fast.
Got the surgery, no chemo… just six weeks of radiation.
Was I scared? Yes.
But I have strong role models in my family.
We don’t just hide in the corner, we fight, we fight, and I want that to rub off on my grandkids.
The day I found out I was officially in the clear I opened up the email, and it’s like, “We did not see any signs of cancer.”
Nothing could ruin that day.
When my doctor told me about KISQALI, I did my research, read everything I could.
Something that can help reduce my risk of cancer coming back?
I was in.
And I'm so glad because I'm doing what I need to do to take care of myself.
I’m Mona, and I am so much more than my breast cancer.
VOICEOVER:
What is KISQALI?
KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:
- in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
- that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
- an aromatase inhibitor as the first endocrine-based therapy; or
- fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy
It is not known if KISQALI is safe and effective in children.
IMPORTANT SAFETY INFORMATION
KISQALI may cause serious side effects, including:
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:
- trouble breathing or shortness of breath
- cough with or without mucus
- chest pain
Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.
- Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
- Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:
- yellowing of your skin or the whites of your eyes (jaundice)
- dark or brown (tea-colored) urine
- feeling very tired
- loss of appetite
- pain on the upper right side of your stomach area (abdomen)
- bleeding or bruising more easily than normal
Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.
What should I tell my health care provider before taking KISQALI?
Before you take KISQALI, tell your health care provider if you:
- have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
- have ever had a heart attack
- have a slow heartbeat (bradycardia)
- have high blood pressure that is not controlled
- have decreased thyroid gland function (hypothyroidism)
- have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
- have fever, chills, or any other signs or symptoms of infection
- have liver problems
- have kidney problems
- are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
- If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
- Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
- Talk to your health care provider about birth control methods that may be right for you during this time
- If you become pregnant or think you are pregnant, tell your health care provider right away
- are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.
What should I avoid while taking KISQALI?
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.
The most common side effects of KISQALI in people with early breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- increased kidney function test
- decreased platelet counts
- nausea
- headache
- tiredness
The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- nausea
- increased kidney function test
- tiredness
- decreased platelet counts
- diarrhea
- vomiting
- headache
- constipation
- hair loss
- cough
- rash
- back pain
- low blood sugar level
KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information at KISQALI.com.
“We all go through tests. This is just another test.” – MONA
As a bus driver, Mona loves taking people where they want to go, but her favorite trips are the ones with her grandkids. When she learned her early breast cancer could return, she spoke to her doctor and knew just where she wanted to take her treatment. Next stop...taking KISQALI with an aromatase inhibitor.
Watch Christine tell her heartfelt story to her daughter.
CHRISTINE:
Oh, is this even on?
Okay... hi, Aubrey, it’s mom.
I’m making this video for you because you already know I have breast cancer, but that’s just part of my story.
I really want to tell you my whole story.
I grew up close to where we live now... before phones had cameras, and social media.
But we still had fun.
Then, one day, my mom’s friend told me my mom, Nana, had breast cancer.
It was the first time I heard about anyone having cancer.
And my mom didn’t even want to talk about it.
Aubrey, it’s okay not to feel okay.
You don’t have to keep those feelings inside.
Years later, I’m a single mom with kids of my own.
And we’re surrounded by the people we love, like Nana.
One night, I was getting ready to go out… and I noticed my left breast looked different.
There was this dimpling.
I knew it was time to go see my doctor.
I went to so many appointments to find out what was going on.
I remember exactly where I was when I got my results.
I was afraid to answer, but I knew it was important.
That’s when I found out I had early breast cancer.
I know you love great grandma, but jokingly, I kind of blamed her because she had big breasts.
But breast cancer really has nothing to do with the size of your breasts.
My type HR-positive, HER2-negative, is different than what Nana had.
When great grandma passed, I saw this hummingbird that reminded me of her.
It was her favorite animal.
And at my first appointment, there it was. Staring down at me.
A sign from great grandma.
Breast cancer is nothing to be ashamed of.
That’s why I love that you come to my appointments with me.
Remember that being strong, doesn’t mean doing it all by yourself.
When I first heard about KISQALI, I must have said it wrong a hundred times.
But if KISQALI can help reduce my risk of cancer from coming back, how could I not say yes?
So much has changed since my diagnosis… but I’m still your mom, that hasn’t changed.
And we still have our girls’ group.
Friends I know we can lean on when things get tough.
Aubrey, we have done so much together already and there’s so much more I want to celebrate with you.
I’m doing more today to help protect my tomorrow.
AUBREY:
Hey mom, what are you doing?
CHRISTINE:
Hey sweetie, I was just thinking about you.
You want to help me make dinner?
AUBREY:
Mmhmm.
VOICEOVER:
What is KISQALI?
KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:
- in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
- that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
- an aromatase inhibitor as the first endocrine-based therapy; or
- fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy
It is not known if KISQALI is safe and effective in children.
IMPORTANT SAFETY INFORMATION
KISQALI may cause serious side effects, including:
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:
- trouble breathing or shortness of breath
- cough with or without mucus
- chest pain
Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.
- Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
- Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:
- yellowing of your skin or the whites of your eyes (jaundice)
- dark or brown (tea-colored) urine
- feeling very tired
- loss of appetite
- pain on the upper right side of your stomach area (abdomen)
- bleeding or bruising more easily than normal
Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.
What should I tell my health care provider before taking KISQALI?
Before you take KISQALI, tell your health care provider if you:
- have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
- have ever had a heart attack
- have a slow heartbeat (bradycardia)
- have high blood pressure that is not controlled
- have decreased thyroid gland function (hypothyroidism)
- have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
- have fever, chills, or any other signs or symptoms of infection
- have liver problems
- have kidney problems
- are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
- If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
- Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
- Talk to your health care provider about birth control methods that may be right for you during this time
- If you become pregnant or think you are pregnant, tell your health care provider right away
- are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.
What should I avoid while taking KISQALI?
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.
The most common side effects of KISQALI in people with early breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- increased kidney function test
- decreased platelet counts
- nausea
- headache
- tiredness
The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- nausea
- increased kidney function test
- tiredness
- decreased platelet counts
- diarrhea
- vomiting
- headache
- constipation
- hair loss
- cough
- rash
- back pain
- low blood sugar level
KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information at KISQALI.com.
“Being strong doesn’t mean doing it all by yourself.” – CHRISTINE
When Christine learned of her early breast cancer diagnosis and the risk of recurrence, she didn't hide them from her daughter. Instead, she made her a personal video to capture her whole story and filled it with lessons of love, and MORE.
Meet Nikki, a devoted baseball mom, former athlete, and sports enthusiast.
NIKKI:
I'm Nikki, and I'm more than just breast cancer.
I’m the daughter of a track star…
“Alright step off, let me show you.”
…a former high school athlete, and a proud mom of two athletic boys.
“He can’t shoot, he can’t shoot!”
My husband coaches our sons’ baseball teams.
What I love about sports is the team bonding, always having each other's backs, always pushing each other forward.
And you just don't know what's going to happen next.
And I bring that mindset into my everyday life and my family.
Like when I did a self-exam, and noticed something just felt off.
And the next day, I called my OB/GYN.
I never expected at that moment I'd be facing my toughest opponent yet... breast cancer.
I remember sitting on my couch, day after day.
I was there with my son when I told him I had cancer.
He didn't fully understand, but he hugged me and he was like, “Oh, mommy, you're so beautiful.”
That was tough.
I had a bilateral mastectomy, chemo, radiation, and breast reconstruction surgeries.
I even had my ovaries and fallopian tubes removed.
After surgery, I thought I was in the clear.
Then, my doctor told me there's still a chance my breast cancer could come back.
That news hit me hard.
You've got to figure out what you're going to do.
What's the plan?
What's my next move?
That's when my doctor and I talked about KISQALI.
When you hear that there's something else out there that can help you, you're just ready to do it.
Nothing is handed to you.
Not in sports, not in life, and certainly not when it comes to cancer.
And you just don't stop at, “I have a diagnosis.”
You look beyond that.
Cancer changed my approach to life.
Just knowing that I'm present for them and show up and be the best version of myself.
I don't live in the past.
I live in the moment, every single day.
“Go, go, go, go, go! Go, Jace, go, go, go!”
Now I put myself first.
I go out to dinner more.
I do my nails.
I even like crafting.
And I'm a better wife, mom, and person because of it.
I'm Nikki, and I'm doing more today to help protect my tomorrow.
VOICEOVER:
What is KISQALI?
KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:
- in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
- that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
- an aromatase inhibitor as the first endocrine-based therapy; or
- fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy
It is not known if KISQALI is safe and effective in children.
IMPORTANT SAFETY INFORMATION
KISQALI may cause serious side effects, including:
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:
- trouble breathing or shortness of breath
- cough with or without mucus
- chest pain
Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.
- Your health care provider should check your heart and do blood tests before and during treatment with KISQALI
- Tell your health care provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:
- yellowing of your skin or the whites of your eyes (jaundice)
- dark or brown (tea-colored) urine
- feeling very tired
- loss of appetite
- pain on the upper right side of your stomach area (abdomen)
- bleeding or bruising more easily than normal
Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.
What should I tell my health care provider before taking KISQALI?
Before you take KISQALI, tell your health care provider if you:
- have any heart problems, including heart failure, irregular heartbeats, and QT prolongation
- have ever had a heart attack
- have a slow heartbeat (bradycardia)
- have high blood pressure that is not controlled
- have decreased thyroid gland function (hypothyroidism)
- have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood
- have fever, chills, or any other signs or symptoms of infection
- have liver problems
- have kidney problems
- are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
- If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
- Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI
- Talk to your health care provider about birth control methods that may be right for you during this time
- If you become pregnant or think you are pregnant, tell your health care provider right away
- are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI
Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.
What should I avoid while taking KISQALI?
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.
The most common side effects of KISQALI in people with early breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- increased kidney function test
- decreased platelet counts
- nausea
- headache
- tiredness
The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:
- decreased white blood cell counts
- decreased red blood cell counts
- increased liver function tests
- infections
- nausea
- increased kidney function test
- tiredness
- decreased platelet counts
- diarrhea
- vomiting
- headache
- constipation
- hair loss
- cough
- rash
- back pain
- low blood sugar level
KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information at KISQALI.com.
“I never expected I’d be facing my toughest opponent yet—breast cancer.” – NIKKI
Nikki loves sports—whether she’s playing them or watching them. See the game plan Nikki and her doctor drew up when she realized her HR+, HER2- early breast cancer could come back.
Get Your KISQALI Appointment Guide
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See more videos featuring patients, doctors, and KISQALI.
HR+: hormone receptor-positive.
All patients featured are real patients compensated for their time.